The core point of the entire Programming Wisdom blogbook.
With every choice, no matter how large or small, we bring some things closer and push some things farther. Just as with compression, the idea is to make the trade offs that bring the things you want closer, and primarily make the things you don't care about harder, so in the end you come out ahead.
And also like compression, there is a large set of things that nobody really needs or wants, and the corresponding trade offs typically are as close as you can get to no-brainers in programming. If your program will ever be maintained at all, your variables shouldn't all be named with single characters, or in languages foreign to the primary maintainers, or with otherwise obviously-bad names. One can argue about how much care to put into naming, but clearly mario.save(thePrincess) is right out for a bit of code that downloads and verifies an XML file.
Long lists of such bad tradeoffs have been collected for your amusement and edification. Let those who have not read the list and pondered it beware.
We can take these large sets of things nobody wants as our baseline. That means (more-or-less by definition) the low-hanging fruit in any methodology or language has already been picked, and in practice, whenever we allow something useful, we must be disallowing something else useful, since we've already kicked out the majority of useless things. This is why the highlighted paragraph I opened this chapter with includes the phrase everything worth talking about has benefits; sure, Whitespace theoretically makes some things easier, but who really cares? And sure, you can construct languages with obvious flaws that can then be simply corrected, but in practice, you are unlikely to run into such a beast on any real project, so who cares about arguing about such hypotheticals? (If you do encounter such a language in the real world, unless you are in the middle of creating a new environment for some sufficiently-good reason, it's probably proof you should run screaming.)
Here is the key sentence for this entire work: Programming wisdom is the ability to correctly determine the costs and benefits of a set of solutions and judge which solution is best.
Of course it sounds obvious when I put it that way, but clearly many people do not think this way. Many people will read this and say Well, duh!, talking the talk about already knowing this, but I can see by actual actions taken that few exhibit a deep, internalized understanding of this principle. There are many subtleties involved with putting this into practice and shortcuts to avoid; people frequently fail to account for entire value categories, let alone judging them correctly.